Key Publications

Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on alpha4 Integrins
C. Sie, L. G. Perez, M. Kreutzfeldt, M. Potthast, C. Ohnmacht, D. Merkler, S. Huber, A. Krug, and T. Korn
J Immunol, 203(6): 1417-1427, 2019
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
G. Garg, A. Muschaweckh, H. Moreno, A. Vasanthakumar, S. Floess, G. Lepennetier, R. Oellinger, Y. Zhan, T. Regen, M. Hiltensperger, C. Peter, L. Aly, B. Knier, L. R. Palam, R. Kapur, M. H. Kaplan, A. Waisman, R. Rad, G. Schotta, J. Huehn, A. Kallies, and T. Korn
Cell Rep, 26(7): 1854-1868 e5, 2019
Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity
B. Knier, M. Hiltensperger, C. Sie, L. Aly, G. Lepennetier, T. Engleitner, G. Garg, A. Muschaweckh, M. Mitsdorffer, U. Koedel, B. Hochst, P. Knolle, M. Gunzer, B. Hemmer, R. Rad, D. Merkler, and T. Korn
Nat Immunol, 19(12): 1341-1351, 2018
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
S. Heink, N. Yogev, C. Garbers, M. Herwerth, L. Aly, C. Gasperi, V. Husterer, A. L. Croxford, K. Moller-Hackbarth, H. S. Bartsch, K. Sotlar, S. Krebs, T. Regen, H. Blum, B. Hemmer, T. Misgeld, T. F. Wunderlich, J. Hidalgo, M. Oukka, S. Rose-John, M. Schmidt-Supprian, A. Waisman, and T. Korn
Nat Immunol, 18(1): 74-85, 2017
Deletional tolerance prevents AQP4-directed autoimmunity in mice
A. L. Vogel, B. Knier, K. Lammens, S. R. Kalluri, T. Kuhlmann, J. L. Bennett, and T. Korn
Eur J Immunol, 47(3): 458-469, 2017

Original Articles

2019

Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study
L. J. Balk, D. Coric, B. Knier, H. G. Zimmermann, R. Behbehani, R. Alroughani, E. H. Martinez-Lapiscina, A. U. Brandt, B. Sanchez-Dalmau, A. Vidal-Jordana, P. Albrecht, V. Koska, J. Havla, M. Pisa, R. C. Nolan, L. Leocani, F. Paul, O. Aktas, X. Montalban, L. J. Balcer, P. Villoslada, O. Outteryck, T. Korn, A. Petzold, and Imsvisual consortium
Mult Scler J Exp Transl Clin, 5(3): 2055217319871582, 2019
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity
C. Fecher, L. Trovo, S. A. Muller, N. Snaidero, J. Wettmarshausen, S. Heink, O. Ortiz, I. Wagner, R. Kuhn, J. Hartmann, R. M. Karl, A. Konnerth, T. Korn, W. Wurst, D. Merkler, S. F. Lichtenthaler, F. Perocchi, and T. Misgeld
Nat Neurosci, 2019
Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on alpha4 Integrins
C. Sie, L. G. Perez, M. Kreutzfeldt, M. Potthast, C. Ohnmacht, D. Merkler, S. Huber, A. Krug, and T. Korn
J Immunol, 203(6): 1417-1427, 2019
Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice
K. Steinbach, I. Vincenti, K. Egervari, M. Kreutzfeldt, F. van der Meer, N. Page, B. Klimek, I. Rossitto-Borlat, G. Di Liberto, A. Muschaweckh, I. Wagner, K. Hammad, C. Stadelmann, T. Korn, O. Hartley, D. D. Pinschewer, and D. Merkler
Sci Transl Med, 11(498), 2019
CSF Protein Concentration Shows No Correlation With Brain Volume Measures
A. Wuschek, S. Grahl, V. Pongratz, T. Korn, J. Kirschke, C. Zimmer, B. Hemmer, and M. Muhlau
Front Neurol, 10: 463, 2019
Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study
R. C. Nolan-Kenney, M. Liu, O. Akhand, P. A. Calabresi, F. Paul, A. Petzold, L. Balk, A. U. Brandt, E. H. Martinez-Lapiscina, S. Saidha, P. Villoslada, A. A. Al-Hassan, R. Behbehani, E. M. Frohman, T. Frohman, J. Havla, B. Hemmer, H. Jiang, B. Knier, T. Korn, L. Leocani, A. Papadopoulou, M. Pisa, H. Zimmermann, S. L. Galetta, L. J. Balcer, and Consortium International Multiple Sclerosis Visual System
Ann Neurol, 85(5): 618-629, 2019
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
G. Garg, A. Muschaweckh, H. Moreno, A. Vasanthakumar, S. Floess, G. Lepennetier, R. Oellinger, Y. Zhan, T. Regen, M. Hiltensperger, C. Peter, L. Aly, B. Knier, L. R. Palam, R. Kapur, M. H. Kaplan, A. Waisman, R. Rad, G. Schotta, J. Huehn, A. Kallies, and T. Korn
Cell Rep, 26(7): 1854-1868 e5, 2019
Optimal Inter-Eye Difference Thresholds by OCT in MS: An International Study
R. C. Nolan, M. Liu, O. Akhand, P. A. Calabresi, F. Paul, A. Petzold, L. Balk, A. U. Brandt, E. H. Martinez-Lapiscina, S. Saidha, P. Villoslada, A. A. Al-Hassan, R. Behbehani, E. M. Frohman, T. Frohman, J. Havla, B. Hemmer, H. Jiang, B. Knier, T. Korn, L. Leocani, A. Papadopoulou, M. Pisa, H. Zimmermann, S. L. Galetta, L. J. Balcer, and Imsvisual Consortium
Ann Neurol, 2019
Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis
N. Feucht, M. Maier, G. Lepennetier, M. Pettenkofer, C. Wetzlmair, T. Daltrozzo, P. Scherm, C. Zimmer, M. M. Hoshi, B. Hemmer, T. Korn, and B. Knier
Mult Scler, 25(2): 224-234, 2019

2018

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity
B. Knier, M. Hiltensperger, C. Sie, L. Aly, G. Lepennetier, T. Engleitner, G. Garg, A. Muschaweckh, M. Mitsdorffer, U. Koedel, B. Hochst, P. Knolle, M. Gunzer, B. Hemmer, R. Rad, D. Merkler, and T. Korn
Nat Immunol, 19(12): 1341-1351, 2018
Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus
J. Breuer, E. Korpos, M. J. Hannocks, T. Schneider-Hohendorf, J. Song, L. Zondler, S. Herich, K. Flanagan, T. Korn, A. Zarbock, T. Kuhlmann, L. Sorokin, H. Wiendl, and N. Schwab
J Neuroinflammation, 15(1): 236, 2018
IL-23 (Interleukin-23)-Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke
M. Gelderblom, M. Gallizioli, P. Ludewig, V. Thom, P. Arunachalam, B. Rissiek, C. Bernreuther, M. Glatzel, T. Korn, T. V. Arumugam, J. Sedlacik, C. Gerloff, E. Tolosa, A. M. Planas, and T. Magnus
Stroke, 49(1): 155-164, 2018
Association of Retinal Ganglion Cell Layer Thickness With Future Disease Activity in Patients With Clinically Isolated Syndrome
H. G. Zimmermann, B. Knier, T. Oberwahrenbrock, J. Behrens, C. Pfuhl, L. Aly, M. Kaminski, M. M. Hoshi, S. Specovius, R. M. Giess, M. Scheel, M. Muhlau, J. Bellmann-Strobl, K. Ruprecht, B. Hemmer, T. Korn, F. Paul, and A. U. Brandt
JAMA Neurol, 75(9): 1071-1079, 2018

2017

Fatigue in multiple sclerosis: Associations with clinical, MRI and CSF parameters
V. Biberacher, P. Schmidt, R. C. Selter, V. Pernpeinter, M. C. Kowarik, B. Knier, D. Buck, M. M. Hoshi, T. Korn, A. Berthele, J. S. Kirschke, C. Zimmer, B. Hemmer, and M. Muhlau
Mult Scler, 2017
Deletional tolerance prevents AQP4-directed autoimmunity in mice
A. L. Vogel, B. Knier, K. Lammens, S. R. Kalluri, T. Kuhlmann, J. L. Bennett, and T. Korn
Eur J Immunol, 47(3): 458-469, 2017
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
S. Heink, N. Yogev, C. Garbers, M. Herwerth, L. Aly, C. Gasperi, V. Husterer, A. L. Croxford, K. Moller-Hackbarth, H. S. Bartsch, K. Sotlar, S. Krebs, T. Regen, H. Blum, B. Hemmer, T. Misgeld, T. F. Wunderlich, J. Hidalgo, M. Oukka, S. Rose-John, M. Schmidt-Supprian, A. Waisman, and T. Korn
Nat Immunol, 18(1): 74-85, 2017
IL-1beta and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) gammadelta T Cells to gammadeltaT17 Cells
A. Muschaweckh, F. Petermann, and T. Korn
J Immunol, 199(8): 2668-2679, 2017
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties
C. K. Prajeeth, J. Kronisch, R. Khorooshi, B. Knier, H. Toft-Hansen, V. Gudi, S. Floess, J. Huehn, T. Owens, T. Korn, and M. Stangel
J Neuroinflammation, 14(1): 204, 2017
Microstructural visual system changes in AQP4-antibody-seropositive NMOSD
F. C. Oertel, J. Kuchling, H. Zimmermann, C. Chien, F. Schmidt, B. Knier, J. Bellmann-Strobl, T. Korn, M. Scheel, A. Klistorner, K. Ruprecht, F. Paul, and A. U. Brandt
Neurol Neuroimmunol Neuroinflamm, 4(3): e334, 2017
Association of Retinal Architecture, Intrathecal Immunity, and Clinical Course in Multiple Sclerosis
B. Knier, G. Leppenetier, C. Wetzlmair, L. Aly, M. M. Hoshi, V. Pernpeintner, V. Biberacher, A. Berthele, M. Muhlau, C. Zimmer, B. Hemmer, and T. Korn
JAMA Neurol, 74(7): 847-856, 2017

2016

Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination
B. Knier, A. Berthele, D. Buck, P. Schmidt, C. Zimmer, M. Muhlau, B. Hemmer, and T. Korn
Mult Scler, 22(7): 893-900, 2016
Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis
B. Knier, P. Schmidt, L. Aly, D. Buck, A. Berthele, M. Muhlau, C. Zimmer, B. Hemmer, and T. Korn
Brain, 2016
Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells
A. Muschaweckh, V. R. Buchholz, A. Fellenzer, C. Hessel, P. A. Konig, S. Tao, R. Tao, M. Heikenwalder, D. H. Busch, T. Korn, W. Kastenmuller, I. Drexler, and G. Gasteiger
J Exp Med, 213(13): 3075-3086, 2016
Fulminant Central Nervous System Nocardiosis in a Patient Treated With Alemtuzumab for Relapsing-Remitting Multiple Sclerosis
H. Penkert, C. Delbridge, N. Wantia, B. Wiestler, and T. Korn
JAMA Neurol, 73(6): 757-9, 2016
Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection
K. Steinbach, I. Vincenti, M. Kreutzfeldt, N. Page, A. Muschaweckh, I. Wagner, I. Drexler, D. Pinschewer, T. Korn, and D. Merkler
J Exp Med, 213(8): 1571-87, 2016
Interleukin-23-Dependent γ/δ T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice
A. Reinhardt, T. Yevsa, T. Worbs, S. Lienenklaus, I. Sandrock, L. Oberdorfer, T. Korn, S. Weiss, R. Forster, and I. Prinz
Arthritis Rheumatol, 68(10): 2476-86, 2016
[Monitoring of blood parameters under course-modified MS therapy : Substance-specific relevance and current recommendations for action]
L. Klotz, A. Berthele, W. Bruck, A. Chan, P. Flachenecker, R. Gold, A. Haghikia, K. Hellwig, B. Hemmer, R. Hohlfeld, T. Korn, T. Kumpfel, M. Lang, V. Limmroth, R. A. Linker, U. Meier, S. G. Meuth, F. Paul, A. Salmen, M. Stangel, B. Tackenberg, H. Tumani, C. Warnke, M. S. Weber, T. Ziemssen, F. Zipp, and H. Wiendl
Nervenarzt, 87(6): 645-59, 2016
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
K. Gobel, S. Pankratz, C. M. Asaridou, A. M. Herrmann, S. Bittner, M. Merker, T. Ruck, S. Glumm, F. Langhauser, P. Kraft, T. F. Krug, J. Breuer, M. Herold, C. C. Gross, D. Beckmann, A. Korb-Pap, M. K. Schuhmann, S. Kuerten, I. Mitroulis, C. Ruppert, M. W. Nolte, C. Panousis, L. Klotz, B. Kehrel, T. Korn, H. F. Langer, T. Pap, B. Nieswandt, H. Wiendl, T. Chavakis, C. Kleinschnitz, and S. G. Meuth
Nat Commun, 7: 11626, 2016

2015

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice
A. Carambia, B. Freund, D. Schwinge, O. T. Bruns, S. C. Salmen, H. Ittrich, R. Reimer, M. Heine, S. Huber, C. Waurisch, A. Eychmuller, D. C. Wraith, T. Korn, P. Nielsen, H. Weller, C. Schramm, S. Luth, A. W. Lohse, J. Heeren, and J. Herkel
J Hepatol, 62(6): 1349-56, 2015
Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis
B. Knier, V. Rothhammer, S. Heink, O. Puk, J. Graw, B. Hemmer, and T. Korn
J Autoimmun, 56: 34-44, 2015

2014

TGF-β-dependent induction of CD4(+)CD25(+)Foxp3(+) Tregs by liver sinusoidal endothelial cells
A. Carambia, B. Freund, D. Schwinge, M. Heine, A. Laschtowitz, S. Huber, D. C. Wraith, T. Korn, C. Schramm, A. W. Lohse, J. Heeren, and J. Herkel
J Hepatol, 61(3): 594-9, 2014
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation
A. Gewies, O. Gorka, H. Bergmann, K. Pechloff, F. Petermann, K. M. Jeltsch, M. Rudelius, M. Kriegsmann, W. Weichert, M. Horsch, J. Beckers, W. Wurst, M. Heikenwalder, T. Korn, V. Heissmeyer, and J. Ruland
Cell Rep, 9(4): 1292-305, 2014
IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1
C. Heinemann, S. Heink, F. Petermann, A. Vasanthakumar, V. Rothhammer, E. Doorduijn, M. Mitsdoerffer, C. Sie, O. Prazeres da Costa, T. Buch, B. Hemmer, M. Oukka, A. Kallies, and T. Korn
Nat Commun, 5: 3770, 2014
α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets
V. Rothhammer, A. Muschaweckh, G. Gasteiger, F. Petermann, S. Heink, D. H. Busch, M. Heikenwalder, B. Hemmer, I. Drexler, and T. Korn
Acta Neuropathol Commun, 2: 27, 2014
Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions
L. Schirmer, R. Srivastava, S. R. Kalluri, S. Bottinger, M. Herwerth, D. Carassiti, B. Srivastava, J. Gempt, J. Schlegel, T. Kuhlmann, T. Korn, R. Reynolds, and B. Hemmer
Ann Neurol, 75(6): 810-28, 2014
Continuous T cell receptor signals maintain a functional regulatory T cell pool
J. C. Vahl, C. Drees, K. Heger, S. Heink, J. C. Fischer, J. Nedjic, N. Ohkura, H. Morikawa, H. Poeck, S. Schallenberg, D. Riess, M. Y. Hein, T. Buch, B. Polic, A. Schonle, R. Zeiser, A. Schmitt-Graff, K. Kretschmer, L. Klein, T. Korn, S. Sakaguchi, and M. Schmidt-Supprian
Immunity, 41(5): 722-36, 2014

2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Consortium International Multiple Sclerosis Genetics, A. H. Beecham, N. A. Patsopoulos, D. K. Xifara, M. F. Davis, A. Kemppinen, C. Cotsapas, T. S. Shah, C. Spencer, D. Booth, A. Goris, A. Oturai, J. Saarela, B. Fontaine, B. Hemmer, C. Martin, F. Zipp, S. D'Alfonso, F. Martinelli-Boneschi, B. Taylor, H. F. Harbo, I. Kockum, J. Hillert, T. Olsson, M. Ban, J. R. Oksenberg, R. Hintzen, L. F. Barcellos, Consortium Wellcome Trust Case Control, Genetics Consortium I. B. D. International, C. Agliardi, L. Alfredsson, M. Alizadeh, C. Anderson, R. Andrews, H. B. Sondergaard, A. Baker, G. Band, S. E. Baranzini, N. Barizzone, J. Barrett, C. Bellenguez, L. Bergamaschi, L. Bernardinelli, A. Berthele, V. Biberacher, T. M. Binder, H. Blackburn, I. L. Bomfim, P. Brambilla, S. Broadley, B. Brochet, L. Brundin, D. Buck, H. Butzkueven, S. J. Caillier, W. Camu, W. Carpentier, P. Cavalla, E. G. Celius, I. Coman, G. Comi, L. Corrado, L. Cosemans, I. Cournu-Rebeix, B. A. Cree, D. Cusi, V. Damotte, G. Defer, S. R. Delgado, P. Deloukas, A. di Sapio, A. T. Dilthey, P. Donnelly, B. Dubois, M. Duddy, S. Edkins, I. Elovaara, F. Esposito, N. Evangelou, B. Fiddes, J. Field, A. Franke, C. Freeman, I. Y. Frohlich, D. Galimberti, C. Gieger, P. A. Gourraud, C. Graetz, A. Graham, V. Grummel, C. Guaschino, A. Hadjixenofontos, H. Hakonarson, C. Halfpenny, G. Hall, P. Hall, A. Hamsten, J. Harley, T. Harrower, and others
Nat Genet, 45(11): 1353-60, 2013
Enriched CD161high CCR6+ γδ T cells in the cerebrospinal fluid of patients with multiple sclerosis
L. Schirmer, V. Rothhammer, B. Hemmer, and T. Korn
JAMA Neurol, 70(3): 345-51, 2013

2012

18F-FDG PET detects inflammatory infiltrates in spinal cord experimental autoimmune encephalomyelitis lesions
D. Buck, A. Forschler, C. Lapa, T. Schuster, P. Vollmar, T. Korn, S. Nessler, C. Stadelmann, A. Drzezga, A. K. Buck, H. J. Wester, C. Zimmer, B. J. Krause, and B. Hemmer
J Nucl Med, 53(8): 1269-76, 2012
Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke
M. Gelderblom, A. Weymar, C. Bernreuther, J. Velden, P. Arunachalam, K. Steinbach, E. Orthey, T. V. Arumugam, F. Leypoldt, O. Simova, V. Thom, M. A. Friese, I. Prinz, C. Holscher, M. Glatzel, T. Korn, C. Gerloff, E. Tolosa, and T. Magnus
Blood, 120(18): 3793-802, 2012
CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation
M. C. Kowarik, S. Cepok, J. Sellner, V. Grummel, M. S. Weber, T. Korn, A. Berthele, and B. Hemmer
J Neuroinflammation, 9: 93, 2012
Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22
H. Raifer, A. J. Mahiny, N. Bollig, F. Petermann, A. Hellhund, K. Kellner, A. Guralnik, K. Reinhard, E. Bothur, M. Huber, S. Bauer, M. Lohning, E. A. Kiss, S. C. Ganal, A. Diefenbach, T. Korn, and M. Lohoff
Eur J Immunol, 42(12): 3189-201, 2012
Potassium channel KIR4.1 as an immune target in multiple sclerosis
R. Srivastava, M. Aslam, S. R. Kalluri, L. Schirmer, D. Buck, B. Tackenberg, V. Rothhammer, A. Chan, R. Gold, A. Berthele, J. L. Bennett, T. Korn, and B. Hemmer
N Engl J Med, 367(2): 115-23, 2012
IL-17A production by renal γδ T cells promotes kidney injury in crescentic GN
J. E. Turner, C. Krebs, A. P. Tittel, H. J. Paust, C. Meyer-Schwesinger, S. B. Bennstein, O. M. Steinmetz, I. Prinz, T. Magnus, T. Korn, R. A. Stahl, C. Kurts, and U. Panzer
J Am Soc Nephrol, 23(9): 1486-95, 2012
Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells
N. Yogev, F. Frommer, D. Lukas, K. Kautz-Neu, K. Karram, D. Ielo, E. von Stebut, H. C. Probst, M. van den Broek, D. Riethmacher, T. Birnberg, T. Blank, B. Reizis, T. Korn, H. Wiendl, S. Jung, M. Prinz, F. C. Kurschus, and A. Waisman
Immunity, 37(2): 264-75, 2012

2011

Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells
J. D. Haas, K. Nistala, F. Petermann, N. Saran, V. Chennupati, S. Schmitz, T. Korn, L. R. Wedderburn, R. Forster, A. Krueger, and I. Prinz
PLoS One, 6(5): e20171, 2011
Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica
S. R. Kalluri, V. Rothhammer, O. Staszewski, R. Srivastava, F. Petermann, M. Prinz, B. Hemmer, and T. Korn
PLoS One, 6(1): e16083, 2011
Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS
M. C. Kowarik, H. L. Pellkofer, S. Cepok, T. Korn, T. Kumpfel, D. Buck, R. Hohlfeld, A. Berthele, and B. Hemmer
Neurology, 76(14): 1214-21, 2011
Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity
J. Loschko, S. Heink, D. Hackl, D. Dudziak, W. Reindl, T. Korn, and A. B. Krug
J Immunol, 187(12): 6346-56, 2011
TNF-α-dependent loss of IKKβ-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis
A. K. Mankan, O. Canli, S. Schwitalla, P. Ziegler, J. Tschopp, T. Korn, and F. R. Greten
Proc Natl Acad Sci U S A, 108(16): 6567-72, 2011
Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE
V. Rothhammer, S. Heink, F. Petermann, R. Srivastava, M. C. Claussen, B. Hemmer, and T. Korn
J Exp Med, 208(12): 2465-76, 2011
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice
C. Weber, S. Meiler, Y. Doring, M. Koch, M. Drechsler, R. T. Megens, Z. Rowinska, K. Bidzhekov, C. Fecher, E. Ribechini, M. A. van Zandvoort, C. J. Binder, I. Jelinek, M. Hristov, L. Boon, S. Jung, T. Korn, M. B. Lutz, I. Forster, M. Zenke, T. Hieronymus, T. Junt, and A. Zernecke
J Clin Invest, 121(7): 2898-910, 2011

2010

Proinflammatory T helper type 17 cells are effective B-cell helpers
M. Mitsdoerffer, Y. Lee, A. Jager, H. J. Kim, T. Korn, J. K. Kolls, H. Cantor, E. Bettelli, and V. K. Kuchroo
Proc Natl Acad Sci U S A, 107(32): 14292-7, 2010
γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism
F. Petermann, V. Rothhammer, M. C. Claussen, J. D. Haas, L. R. Blanco, S. Heink, I. Prinz, B. Hemmer, V. K. Kuchroo, M. Oukka, and T. Korn
Immunity, 33(3): 351-63, 2010
Active immunization with amyloid-β 1-42 impairs memory performance through TLR2/4-dependent activation of the innate immune system
P. Vollmar, J. S. Kullmann, B. Thilo, M. C. Claussen, V. Rothhammer, H. Jacobi, J. Sellner, S. Nessler, T. Korn, and B. Hemmer
J Immunol, 185(10): 6338-47, 2010

2009

Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells
A. Awasthi, L. Riol-Blanco, A. Jager, T. Korn, C. Pot, G. Galileos, E. Bettelli, V. K. Kuchroo, and M. Oukka
J Immunol, 182(10): 5904-8, 2009

2008

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
T. Korn, M. Mitsdoerffer, A. L. Croxford, A. Awasthi, V. A. Dardalhon, G. Galileos, P. Vollmar, G. L. Stritesky, M. H. Kaplan, A. Waisman, V. K. Kuchroo, and M. Oukka
Proc Natl Acad Sci U S A, 105(47): 18460-5, 2008
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
F. J. Quintana, A. S. Basso, A. H. Iglesias, T. Korn, M. F. Farez, E. Bettelli, M. Caccamo, M. Oukka, and H. L. Weiner
Nature, 453(7191): 65-71, 2008
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-β-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression
S. Xiao, H. Jin, T. Korn, S. M. Liu, M. Oukka, B. Lim, and V. K. Kuchroo
J Immunol, 181(4): 2277-84, 2008

2007

Anti-thymocyte globulin (ATG) prevents autoimmune encephalomyelitis by expanding myelin antigen-specific Foxp3+ regulatory T cells
D. T. Chung, T. Korn, J. Richard, M. Ruzek, A. P. Kohm, S. Miller, S. Nahill, and M. Oukka
Int Immunol, 19(8): 1003-10, 2007
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
T. Korn, E. Bettelli, W. Gao, A. Awasthi, A. Jager, T. B. Strom, M. Oukka, and V. K. Kuchroo
Nature, 448(7152): 484-7, 2007
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
T. Korn, J. Reddy, W. Gao, E. Bettelli, A. Awasthi, T. R. Petersen, B. T. Backstrom, R. A. Sobel, K. W. Wucherpfennig, T. B. Strom, M. Oukka, and V. K. Kuchroo
Nat Med, 13(4): 423-31, 2007
Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes
T. Magnus, T. Coksaygan, T. Korn, H. Xue, T. V. Arumugam, M. R. Mughal, D. M. Eckley, S. C. Tang, L. Detolla, M. S. Rao, R. Cassiani-Ingoni, and M. P. Mattson
J Neurosci Res, 85(10): 2126-37, 2007
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function
S. Xiao, N. Najafian, J. Reddy, M. Albin, C. Zhu, E. Jensen, J. Imitola, T. Korn, A. C. Anderson, Z. Zhang, C. Gutierrez, T. Moll, R. A. Sobel, D. T. Umetsu, H. Yagita, H. Akiba, T. Strom, M. H. Sayegh, R. H. DeKruyff, S. J. Khoury, and V. K. Kuchroo
J Exp Med, 204(7): 1691-702, 2007

2006

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
E. Bettelli, Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo
Nature, 441(7090): 235-8, 2006

2005

Lipooligosaccharide of Campylobacter jejuni prevents myelin-specific enteral tolerance to autoimmune neuritis--a potential mechanism in Guillain-Barre syndrome?
S. Jung, S. Zimmer, E. Luneberg, M. Frosch, H. Karch, T. Korn, and K. V. Toyka
Neurosci Lett, 381(1-2): 175-8, 2005
Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor-α
T. Korn, T. Magnus, and S. Jung
FASEB J, 19(13): 1878-80, 2005
Interaction with antigen-specific T cells regulates expression of the lactate transporter MCT1 in primary rat astrocytes: specific link between immunity and homeostasis
T. Korn, T. Magnus, and S. Jung
Glia, 49(1): 73-83, 2005
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS
T. Magnus, B. Schreiner, T. Korn, C. Jack, H. Guo, J. Antel, I. Ifergan, L. Chen, F. Bischof, A. Bar-Or, and H. Wiendl
J Neurosci, 25(10): 2537-46, 2005

2004

Biphasic form of experimental autoimmune neuritis in dark Agouti rats and its oral therapy by antigen-specific tolerization
S. Jung, S. Gaupp, T. Korn, G. Kollner, H. P. Hartung, and K. V. Toyka
J Neurosci Res, 75(4): 524-35, 2004
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion
T. Korn, T. Magnus, K. Toyka, and S. Jung
J Leukoc Biol, 76(5): 950-60, 2004
Impaired volitional closure of the left eyelid after right anterior cerebral artery infarction: apraxia due to interhemispheric disconnection?
T. Korn, W. Reith, and G. Becker
Arch Neurol, 61(2): 273-5, 2004
Chronically stimulated microglial cells do no longer alter their immune functions in response to the phagocytosis of apoptotic cells
T. Magnus, T. Korn, and S. Jung
J Neuroimmunol, 155(1-2): 64-72, 2004

2003

Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen priming
T. Korn, K. D. Fischer, I. Girkontaite, G. Kollner, K. Toyka, and S. Jung
J Neuroimmunol, 139(1-2): 17-26, 2003

2001

The plasma membrane-associated protein RS1 decreases transcription of the transporter SGLT1 in confluent LLC-PK1 cells
T. Korn, T. Kuhlkamp, C. Track, I. Schatz, K. Baumgarten, V. Gorboulev, and H. Koepsell
J Biol Chem, 276(48): 45330-40, 2001
Suppression of experimental autoimmune neuritis by leflunomide
T. Korn, K. Toyka, H. P. Hartung, and S. Jung
Brain, 124(Pt 9): 1791-802, 2001

Review Articles

2018

Interleukin-6: designing specific therapeutics for a complex cytokine
C. Garbers, S. Heink, T. Korn, and S. Rose-John
Nat Rev Drug Discov, 2018
The Interleukin (IL)-23/T helper (Th)17 Axis in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
M. Hiltensperger and T. Korn
Cold Spring Harb Perspect Med, 8(1), 2018

2017

T cell responses in the central nervous system
T. Korn and A. Kallies
Nat Rev Immunol, 2017
Disentangling the manifold functions of RORgammat
T. Korn
Nat Immunol, 18(10): 1059-1060, 2017

2016

From Leflunomide to Teriflunomide: Drug development and Immunosuppressive Oral Drugs in the Treatment of Multiple Sclerosis
L. Aly, B. Hemmer, and T. Korn
Curr Neuropharmacol, 2016
Dendritic cells in central nervous system autoimmunity
C. Sie and T. Korn
Semin Immunopathol, 2016

2015

Role of the innate and adaptive immune responses in the course of multiple sclerosis
B. Hemmer, M. Kerschensteiner, and T. Korn
Lancet Neurol, 14(4): 406-19, 2015
[Current aspects of therapy conversion for multiple sclerosis]
P. Kolber, F. Luessi, S. G. Meuth, L. Klotz, T. Korn, C. Trebst, B. Tackenberg, B. Kieseier, T. Kumpfel, V. Fleischer, H. Tumani, B. Wildemann, M. Lang, P. Flachenecker, U. Meier, W. Bruck, V. Limmroth, A. Haghikia, H. P. Hartung, M. Stangel, R. Hohlfeld, B. Hemmer, R. Gold, H. Wiendl, and F. Zipp
Nervenarzt, 86(10): 1236-47, 2015
B cells assume the command
A. Waisman and T. Korn
Sci Transl Med, 7(310): 310fs42, 2015

2014

Novel monoclonal antibodies for therapy of multiple sclerosis
B. Knier, B. Hemmer, and T. Korn
Expert Opin Biol Ther, 14(4): 503-13, 2014
Th17 cells in central nervous system autoimmunity
C. Sie, T. Korn, and M. Mitsdoerffer
Exp Neurol, 262 Pt A: 18-27, 2014

2013

Immunology of neuromyelitis optica: a T cell-B cell collaboration
M. Mitsdoerffer, V. Kuchroo, and T. Korn
Ann N Y Acad Sci, 1283: 57-66, 2013

2012

Immune mechanisms of new therapeutic strategies in MS: teriflunomide
M. C. Claussen and T. Korn
Clin Immunol, 142(1): 49-56, 2012
Development and function of interleukin 17-producing γδ T cells
T. Korn and F. Petermann
Ann N Y Acad Sci, 1247: 34-45, 2012

2011

Cytokines and effector T cell subsets causing autoimmune CNS disease
F. Petermann and T. Korn
FEBS Lett, 585(23): 3747-57, 2011

2010

How T cells take developmental decisions by using the aryl hydrocarbon receptor to sense the environment
T. Korn
Proc Natl Acad Sci U S A, 107(48): 20597-8, 2010
Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis
T. Korn, M. Mitsdoerffer, and V. K. Kuchroo
Results Probl Cell Differ, 51: 43-74, 2010

2009

IL-17 and Th17 Cells
T. Korn, E. Bettelli, M. Oukka, and V. K. Kuchroo
Annu Rev Immunol, 27: 485-517, 2009
Interleukin-17 and type 17 helper T cells
P. Miossec, T. Korn, and V. K. Kuchroo
N Engl J Med, 361(9): 888-98, 2009

2008

Induction and effector functions of T(H)17 cells
E. Bettelli, T. Korn, M. Oukka, and V. K. Kuchroo
Nature, 453(7198): 1051-7, 2008
Role of Th1 and Th17 cells in organ-specific autoimmunity
V. Dardalhon, T. Korn, V. K. Kuchroo, and A. C. Anderson
J Autoimmun, 31(3): 252-6, 2008
Pathophysiology of multiple sclerosis
T. Korn
J Neurol, 255 Suppl 6: 2-6, 2008

2007

Th17: the third member of the effector T cell trilogy
E. Bettelli, T. Korn, and V. K. Kuchroo
Curr Opin Immunol, 19(6): 652-7, 2007
The dynamics of effector T cells and Foxp3+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis
T. Korn, A. C. Anderson, E. Bettelli, and M. Oukka
J Neuroimmunol, 191(1-2): 51-60, 2007
Dynamics of antigen-specific regulatory T-cells in the context of autoimmunity
T. Korn and M. Oukka
Semin Immunol, 19(4): 272-8, 2007
Th17 cells: effector T cells with inflammatory properties
T. Korn, M. Oukka, V. Kuchroo, and E. Bettelli
Semin Immunol, 19(6): 362-71, 2007
Autoimmune modulation of astrocyte-mediated homeostasis
T. Korn, M. Rao, and T. Magnus
Neuromolecular Med, 9(1): 1-16, 2007